资源类型

期刊论文 1110

年份

2024 1

2023 92

2022 103

2021 72

2020 83

2019 59

2018 52

2017 48

2016 46

2015 53

2014 50

2013 40

2012 42

2011 37

2010 53

2009 48

2008 40

2007 37

2006 28

2005 26

展开 ︾

关键词

数学模型 13

模型试验 9

数值模拟 8

模型 7

不确定性 5

COVID-19 4

GM(1 3

计算机模拟 3

1)模型 2

DX桩 2

D区 2

Preissmann格式 2

SARS 2

TRIZ 2

Weibull分布 2

k-ε模型 2

不确定性评估 2

临震信号 2

云模型 2

展开 ︾

检索范围：

排序： 展示方式：

Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U. Farrukh Hameed, Yangming Zhu, Lei Jin, Jie Zhang, Junfeng Lu, Jinsong Wu

《医学前沿（英文）》 2021年 第15卷 第4期   页码 562-574 doi: 10.1007/s11684-020-0771-z

摘要： The protection of language function is one of the major challenges of brain surgery. Over the past century, neurosurgeons have attempted to seek the optimal strategy for the preoperative and intraoperative identification of language-related brain regions. Neurosurgeons have investigated the neural mechanism of language, developed neurolinguistics theory, and provided unique evidence to further understand the neural basis of language functions by using intraoperative cortical and subcortical electrical stimulation. With the emergence of modern neuroscience techniques and dramatic advances in language models over the last 25 years, novel language mapping methods have been applied in the neurosurgical practice to help neurosurgeons protect the brain and reduce morbidity. The rapid advancements in brain–computer interface have provided the perfect platform for the combination of neurosurgery and neurolinguistics. In this review, the history of neurolinguistics models, advancements in modern technology, role of neurosurgery in language mapping, and modern language mapping methods (including noninvasive neuroimaging techniques and invasive cortical electroencephalogram) are presented.

关键词： neurolinguistics     language mapping     dual pathway model     neurosurgery    

HTML PDF 收藏

Development of a hydrodynamic model and the corresponding virtual software for dual-loop circulating

Shanwei Hu, Xinhua Liu

《化学科学与工程前沿（英文）》 2021年 第15卷 第3期   页码 579-590 doi: 10.1007/s11705-020-1953-6

摘要： Dual-loop circulating fluidized bed (CFB) reactors have been widely applied in industry because of their good heat and mass transfer characteristics and continuous handling ability. However, the design of such reactors is notoriously difficult owing to the poor understanding of the underlying mechanisms, meaning it has been heavily based on empiricism and stepwise experiments. Modeling the gas-solid CFB system requires a quantitative description of the multiscale heterogeneity in the sub-reactors and the strong coupling between them. This article proposed a general method for modeling multi-loop CFB systems by utilizing the energy minimization multiscale (EMMS) principle. A full-loop modeling scheme was implemented by using the EMMS model and/or its extension models to compute the hydrodynamic parameters of the sub-reactors, to achieve the mass conservation and pressure balance in each circulation loop. Based on the modularization strategy, corresponding interactive simulation software was further developed to facilitate the flexible creation and fast modeling of a customized multi-loop CFB reactor. This research can be expected to provide quantitative references for the design and scale-up of gas-solid CFB reactors and lay a solid foundation for the realization of virtual process engineering.

关键词： multi-loop circulating fluidized bed     mathematical modeling     energy minimization multiscale     virtual fluidization     mesoscale structure    

HTML PDF 收藏

Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1637-9

摘要：

● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.

关键词： Xylose fermentation     Caproate     Low temperature     Bifidobacterium     FAB pathway     RBO pathway    

HTML PDF 收藏

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

《医学前沿（英文）》 2023年 第17卷 第4期   页码 714-728 doi: 10.1007/s11684-022-0959-5

摘要： FRMD6, a member of the 4.1 ezrin–radixin–moesin domain-containing protein family, has been reported to inhibit tumor progression in multiple cancers. Here, we demonstrate the involvement of FRMD6 in lung cancer progression. We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues. In addition, the enhanced expression of FRMD6 is associated with poor outcomes in patients with lung squamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, P = 0.0330). Cell migration and proliferation in vitro and tumor formation in vivo are promoted by FRMD6 but are suppressed by the depletion of FRMD6. Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of the mTOR signaling pathway. FRMD6 markedly enhances the interaction between mTOR and S6K, subsequently increasing the levels of endogenous pS6K and downstream pS6 in lung cancer cells. Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6−/− gene KO MEFs and mice. Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway.

关键词： FRMD6     lung cancer     mTOR pathway    

HTML PDF 收藏

Pathway to energy technical innovation and commercialization based on Internet plus DES

Huiping LIU

《能源前沿（英文）》 2016年 第10卷 第1期   页码 65-78 doi: 10.1007/s11708-015-0391-5

摘要： The distributed energy system (DES) is a type of energy cascade utilization on the client side or close to the client, and it has become an important option of global energy transformation. In China, based on the experience of demonstration projects, the DES is now being commercialized. Under the new opportunity of energy production and consumption promoted by the national “Internet Plus” action plan, the development of the DES was reviewed in this paper; four categories of market demand and five key issues for DES deployment were analyzed; five types of potential DES users and five key points of technical path implementation proposed based on many years of engineering practices and hundreds of project case studies were proposed. 4E elements should be used to evaluate and choose the project and lead the innovation model of DES by energy production and consumption revolution with the sustainable development of the Internet plus DES. The future innovation models include intelligent energy modularity and menu-type services with the demands of the client side, and the kind of new thinking for DES services that “you are in charge of your own energy production and consumption, while we are also at service when needed for installation and maintenance.” The aim of innovation mode is to give the energy sovereign back to the people, and form a perfect Internet plus DES ecosystem.

关键词： “Internet Plus”     distributed energy system (DES)     business model     technical innovation     commercialization     DES industry ecosystem     energy revolution    

HTML PDF 收藏

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 157-162 doi: 10.1007/s11684-011-0128-8

摘要： At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management, evidence-based medicine, operational research and health economics. Such concepts provide examples and experiences, on which the application of clinical pathway in Chinese medicine practice in China can be based.

关键词： evidence-based medicine     clinical pathway     methodology     concept     technical difficulty    

HTML PDF 收藏

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 403-409 doi: 10.1007/s11684-017-0522-y

摘要：

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.

关键词： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle cells    

HTML PDF 收藏

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

《医学前沿（英文）》 2022年 第16卷 第4期   页码 637-650 doi: 10.1007/s11684-021-0864-3

摘要： Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment. We tested the potential effect of apigenin, a natural flavonoid with anticancer, anti-inflammatory, and antioxidant activities, on neomycin-induced ototoxicity in cochlear hair cells in vitro. Results showed that apigenin significantly ameliorated the loss of hair cells and the accumulation of reactive oxygen species upon neomycin injury. Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway was activated by apigenin treatment. Disruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stress and subsequent apoptosis of hair cells. This study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying mechanism.

关键词： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

HTML PDF 收藏

Experimental and kinetic study on laminar flame speeds of ammonia/syngas/air at a high temperature and elevated pressure

《能源前沿（英文）》 2022年 第16卷 第2期   页码 263-276 doi: 10.1007/s11708-021-0791-7

摘要： The laminar flame speeds of ammonia mixed with syngas at a high pressure, temperature, and different syngas ratios were measured. The data obtained were fitted at different pressures, temperatures, syngas ratios, and equivalence ratios. Four kinetic models (the Glarborg model, Shrestha model, Mei model, and Han model) were compared and validated with experimental data. Pathway, sensitivity and radical pool analysis are conducted to find out the deep kinetic insight on ammonia oxidation and NO formation. The pathway analysis shows that H abstraction reactions and NHi combination reactions play important roles in ammonia oxidation. NO formation is closely related to H, OH, the O radical produced, and formation reactions. NO is mainly formed from reaction, HNO+ H= NO+ H2. Furthermore, both ammonia oxidation and NO formation are sensitive to small radical reactions and ammonia related reactions.

关键词： ammonia mixed with syngas     laminar flame speed     kinetic model     sensitivity analysis     pathway analysis    

HTML PDF 收藏

Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 285-293 doi: 10.1007/s11684-014-0350-2

摘要：

Catharanthus roseus is one of the most extensively investigated medicinal plants, which can produce more than 130 alkaloids, including the powerful antitumor drugs vinblastine and vincristine. Here we review the recent advances in the biosynthetic pathway of terpenoid indole alkaloids (TIAs) in C. roseus, and the identification and characterization of the corresponding enzymes involved in this pathway. Strictosidine is the central intermediate in the biosynthesis of different TIAs, which is formed by the condensation of secologanin and tryptamine. Secologanin is derived from terpenoid (isoprenoid) biosynthetic pathway, while tryptamine is derived from indole biosynthetic pathway. Then various specific end products are produced by different routes during downstream process. Although many genes and corresponding enzymes have been characterized in this pathway, our knowledge on the whole TIA biosynthetic pathway still remains largely unknown up to date. Full elucidation of TIA biosynthetic pathway is an important prerequisite to understand the regulation of the TIA biosynthesis in the medicinal plant and to produce valuable TIAs by synthetic biological technology.

关键词： Catharanthus roseus     terpenoidindole alkaloids     biosynthetic pathway     vinblastine     vincristine    

HTML PDF 收藏

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 68-78 doi: 10.1007/s11684-014-0308-4

摘要：

Neural tube defects (NTDs) are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.

关键词： planar cell polarity     neural tube defects     rare mutations    

HTML PDF 收藏

A novel task-oriented framework for dual-arm robotic assembly task

《机械工程前沿（英文）》 2021年 第16卷 第3期   页码 528-545 doi: 10.1007/s11465-021-0638-2

摘要： In industrial manufacturing, the deployment of dual-arm robots in assembly tasks has become a trend. However, making the dual-arm robots more intelligent in such applications is still an open, challenging issue. This paper proposes a novel framework that combines task-oriented motion planning with visual perception to facilitate robot deployment from perception to execution and finish assembly problems by using dual-arm robots. In this framework, visual perception is first employed to track the effects of the robot behaviors and observe states of the workpieces, where the performance of tasks can be abstracted as a high-level state for intelligent reasoning. The assembly task and manipulation sequences can be obtained by analyzing and reasoning the state transition trajectory of the environment as well as the workpieces. Next, the corresponding assembly manipulation can be generated and parameterized according to the differences between adjacent states by combining with the prebuilt knowledge of the scenarios. Experiments are set up with a dual-arm robotic system (ABB YuMi and an RGB-D camera) to validate the proposed framework. Experimental results demonstrate the effectiveness of the proposed framework and the promising value of its practical application.

关键词： dual-arm assembly     AI reasoning     intelligent system     task-oriented motion planning     visual perception    

HTML PDF 收藏

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

null

《医学前沿（英文）》 2012年 第6卷 第3期   页码 248-262 doi: 10.1007/s11684-012-0206-6

摘要：

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.

关键词： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

HTML PDF 收藏

Improved nitrogen removal in dual-contaminated surface water by photocatalysis

Yongming ZHANG, Rong YAN, Zhen ZOU, Jiewei WANG, Bruce E. RITTMANN

《环境科学与工程前沿（英文）》 2012年 第6卷 第3期   页码 428-436 doi: 10.1007/s11783-012-0401-3

摘要： River waters in China have dual contamination by nutrients and recalcitrant organic compounds. In principle, the organic compounds could be used to drive denitrification of nitrate, thus arresting eutrophication potential, if the recalcitrant organics could be made bioavailable. This study investigated the potential to make the recalcitrant organics bioavailable through photocatalysis. Batch denitrification tests in a biofilm reactor demonstrated that dual-contaminated river water was short of available electron donor, which resulted in low total nitrogen (TN) removal by denitrification. However, the denitrification rate was increased significantly by adding glucose or by making the organic matters of the river water more bioavailable through photocatalysis. Photocatalysis for 15 min increased the Chemical Oxygen Demand (COD) of the river water from 53 to 84 mg·L and led to a 4-fold increase in TN removal. The increase in TN removal gave the same effect as adding 92 mg·L of glucose. During the photocatalysis experiments, the COD increased because photocatalysis transformed organic molecules from those that are resistant to dichromate oxidation in the COD test to those that can be oxidized by dichromate. This phenomenon was verified by testing photocatalysis of pyridine added to the river water. These findings point to the potential for N removal via denitrification after photocatalysis, and they also suggest that the rivers in China may be far more polluted than indicated by COD assays.

关键词： dual contamination     eutrophication     photocatalysis     remediation     surface water    

HTML PDF 收藏

Correlated channel model-based secure communications in dual-hop wireless communication networks Article

Zhen-hua YUAN, Chen CHEN, Xiang CHENG, Guo-cheng LV, Liu-qing YANG, Ye JIN

《信息与电子工程前沿（英文）》 2017年 第18卷 第6期   页码 796-807 doi: 10.1631/FITEE.1700023

摘要： 主要研究在相关信道模型条件下两跳无线通信网络的中继物理层安全波束成形方案设计问题。系统模型由1个发送节点、1个合法接收节点、1个窃听节点和1个采用放大转发策略的中继节点构成，其中中继节点装备多天线，而其他节点都装备单天线，窃听节点靠近合法接收节点进行窃听，从而使得二者与中继节点之间的信道具有相关性。中继节点无法获得窃听信道的瞬时信道状态信息，只可获得合法信道的瞬时状态信息，以及合法信道与窃听信道之间的相关性信息，据此中继节点可推导出窃听信道状态的条件概率分布。以系统近似遍历安全容量为优化目标，研究了2种中继波束成形方案：1最大化合法信道容量的“广义匹配转发方案”；2“普通阶波束成形方案”。另外，还讨论了基于遍历安全容量下界的“下界最优化波束成形方案”。与上述两方案比对，“广义匹配转发方案”是最优的秩-1方案，“普通阶波束成形方案”则是基于近似遍历安全容量的迭代最优的中继转发方案。通过仿真对各波束成形方案的性能进行比较，验证了本文的分析。从仿真结果还可以看出：当中继节点发送功率较低，或者第二跳信道增益较低时，“广义匹配转发方案”的性能优于“普通阶波束成形方案”。

关键词： 物理层安全；中继波束成形；相关信道；遍历安全速率；凸优化    

HTML PDF 收藏

标题 作者 时间 类型 操作

Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U. Farrukh Hameed, Yangming Zhu, Lei Jin, Jie Zhang, Junfeng Lu, Jinsong Wu

期刊论文

Development of a hydrodynamic model and the corresponding virtual software for dual-loop circulating

Shanwei Hu, Xinhua Liu

期刊论文

Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

期刊论文

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

期刊论文

Pathway to energy technical innovation and commercialization based on Internet plus DES

Huiping LIU

期刊论文

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

期刊论文

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

期刊论文

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

期刊论文

Experimental and kinetic study on laminar flame speeds of ammonia/syngas/air at a high temperature and elevated pressure

期刊论文

Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

null

期刊论文

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

null

期刊论文

A novel task-oriented framework for dual-arm robotic assembly task

期刊论文

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

null

期刊论文

Improved nitrogen removal in dual-contaminated surface water by photocatalysis

Yongming ZHANG, Rong YAN, Zhen ZOU, Jiewei WANG, Bruce E. RITTMANN

期刊论文

Correlated channel model-based secure communications in dual-hop wireless communication networks

Zhen-hua YUAN, Chen CHEN, Xiang CHENG, Guo-cheng LV, Liu-qing YANG, Ye JIN

期刊论文